An optimised multi-arm multi-stage clinical trial design for unknown variance
نویسندگان
چکیده
منابع مشابه
Optimal design for multi-arm multi-stage clinical trials
In early stages of drug development there is often uncertainty about the most promising among a set of different treatments. In order to ensure the best use of resources it is important to decide which, if any, of the treatments should be taken forward for further testing. Multi-arm multi-stage (MAMS) trials provide gains in efficiency over separate randomised trials of each treatment. They all...
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BACKGROUND Randomised controlled trials are becoming increasingly costly and time-consuming. In 2011, Royston and colleagues proposed a particular class of multi-arm multi-stage (MAMS) designs intended to speed up the evaluation of new treatments in phase II and III clinical trials. Their design, which controls the type I error rate and power for each pairwise comparison, discontinues randomisa...
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ژورنال
عنوان ژورنال: Contemporary Clinical Trials
سال: 2018
ISSN: 1551-7144
DOI: 10.1016/j.cct.2018.02.011